Healthcare-Associated Infections (HAIs) in hospitals have garnered considerable attention in recent years and are the focus of multiple national and state reporting requirements and prevention initiatives. Small rural hospitals, however, generally have less experience in HAI reporting and fewer infection control staff resources than urban facilities which are often the focus of these initiatives. The purpose of this project was to identify successful evidence-based programs and strategies for reducing and preventing HAIs that can be replicated in CAHs. The project culminated in a report that profiles these identified programs and strategies.